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Heart: Alive in Seattle
Heart: Alive in Seattle
Music's most famous sisters, Ann and Nancy Wilson, have been successfully writing and performing chart-toppers since their 1975 debut album. From acoustic to folk to hard-driving rock 'n' roll, the ladies instill emotional energy into every song. This special hometown concert showcases a rich musical legacy that's distinctively Heart!
SONGS: Barracuda, Sister Wild Rose, Mistral Wind, Wild Child, Dog and Butterfly, Magic Man, Crazy on You, Dreamboat Annie, Love Alive, These Dreams, Alone, Two Faces of Eve, Break the Rock, Heaven, Straight On, Black Dog, The Witch, Mona Lisa and Mad Hatters, Battle of Evermore.
Sisters Ann and Nancy Wilson and the rest of Heart are in good form in this solid if unspectacular 100-minute concert video, shot in 2002 in their hometown of Seattle. The sisters, of course, are a good deal older than in Heart's '70s heyday, and their bandmates have changed, but the group's sound, led by Ann's powerful vocals and Nancy's instrumental versatility, hasn't changed much; that's a good thing for those who revel in the likes of "Barracuda," "Magic Man," and other oldies. There are several brand-new songs here as well, and the ongoing influence of Led Zeppelin is readily apparent, not only in the covers of Zep classics like "Black Dog" and "The Battle of Evermore" but also in Heart's commingling of pastoral acoustic sounds and hard rock. And after 19 songs, even the most ardent Heart lovers should be well satisfied. --Sam Graham
Heart: Alive in Seattle
Open access journal of the Ferrata-Storti Foundation, a non-profit organization
Open access journal of the Ferrata-Storti Foundation, a non-profit organization
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This open-label, single-arm study investigated the long-term efficacy of tafasitamab plus lenalidomide in 81 patients with relapsed/refractory diffuse large B-cell lymphoma. The response rate was 57.5%, including complete responses in 40.0% of patients, and the median duration of response was 43.9 months. This treatment is a valuable option for patients not eligible for autologous stem-cell transplantation.
Grey zone lymphoma is a B-cell lymphoma, unclassifiable, with features intermediate between those of large B-cell lymphoma and classic Hodgkin lymphoma. The in-depth study of the two adolescent patients described in this case report expands the clinicopathological and genomic spectrum of this rare pediatric disease. Moreover, it provides information on their response to treatment.
The clinical picture of 56 patients with congenital amegakaryocytic thrombocytopenia due to MPL mutations was much more varied than previously thought. Twenty-five per cent of them had no signs of thrombocytopenia at birth, and 50% had non-hematologic defects. Pancytopenia developed in (nearly) all patients and hematopoietic stem-cell transplantation was effective in 87% of cases.
Sickle red blood cells exhibit abnormal adhesion to laminin mediated by Lu/BCAM protein at their surface. This study provides evidence of the involvement of oxidative stress in post-translational modifications of Lu/BCAM which impact the protein’s distribution and cis-interaction with glycophorin C at the cell surface activating its adhesive function in dense sickle red cells. The authors speculate that antioxidant drugs might attenuate this phenomenon.